Thailanstatin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Thailanstatin A 是一种超强效的真核 RNA 剪接抑制剂 ( IC 50 =650 nM)。

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .(In Vitro):Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 . Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) .

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Others

Other Targets

AChR|Antifection|COX-2|PPAR

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1426953-21-0

535.63

C28H41NO9

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (466.74 mM)

C[C@@H](/C=C\C(N[C@H]1[C@@H](C)O[C@@H](C/C=C(\C)/C=C/[C@H]([C@H]2O)O[C@H](CC(O)=O)C[C@]22OC2)[C@@H](C)C1)=O)OC(C)=O

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(-20℃)

With Ice Pack

≥ 2 years